Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505166 | 0.88 | GAA (0.60) | LMNAMAPTKDM4ESGMS2S1PR4 | |
| SCHEMBL1505120 | 0.86 | S1PR4 (0.52) | LMNAMAPTKDM4ESGMS2S1PR4 | |
| SCHEMBL12505380 | 0.86 | LMNA (0.48) | LMNAHTR2CHTR2BMAPTKDM4E | |
| SCHEMBL4359950 | 0.85 | TSHR (0.53) | LMNAHTR2CHTR2BMAPTKDM4E | |
| SCHEMBL11364359 | 0.84 | ALDH1A1 (0.55) | LMNAHTR2CMAPTKDM4ETSHR | |
| SCHEMBL1505088 | 0.84 | GAA (0.56) | LMNAMAPTKDM4ETSHRGAA | |
| SCHEMBL11360893 | 0.83 | PTPN11 (0.50) | LMNAHTR2BMAPTKDM4ESGMS2 | |
| SCHEMBL3385153 | 0.82 | TSHR (0.50) | LMNAHTR2CHTR2BMAPTTSHR | |
| SCHEMBL257135 | 0.80 | LMNA (0.61) | LMNAMAPTTSHRGAAALDH1A1 | |
| SCHEMBL4366901 | 0.79 | ALDH1A1 (0.44) | LMNAHTR2CHTR2BMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4278680-A | Hypoglycaemically and hypolipidaemically active derivatives of phenylacetic acid | BOEHRINGER MANNHEIM GMBH (DE) | 1981-07-14 | — | — | US | disclosed |
| US-4207341-A | Hypoglycaemically and hypolipidaemically active derivatives of phenylacetic acid | BOEHRINGER-MANNHEIM GMBH (DE) | 1980-06-10 | — | — | US | disclosed |