Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11373650 | 0.90 | EGLN3 (0.46) | CYP19A1TBXAS1EGLN3 | |
| SCHEMBL11377610 | 0.88 | ACHE (0.39) | ALDH1A1CYP19A1TBXAS1EGLN3 | |
| SCHEMBL11372860 | 0.88 | ACHE (0.39) | KDM4EALDH1A1TBXAS1EGLN3LMNA | |
| SCHEMBL11158189 | 0.88 | MEN1 (0.40) | KDM4EALDH1A1TBXAS1EGLN3LMNA | |
| SCHEMBL11383874 | 0.88 | EGLN3 (0.38) | ALDH1A1TBXAS1EGLN3 | |
| SCHEMBL11375813 | 0.86 | TBXAS1 (0.39) | ALDH1A1CYP19A1TBXAS1EGLN3 | |
| SCHEMBL11376963 | 0.85 | TBXAS1 (0.41) | CYP19A1TBXAS1EGLN3LMNANOS1 | |
| SCHEMBL11381987 | 0.85 | ACHE (0.42) | KDM4EALDH1A1CYP19A1TBXAS1LMNA | |
| SCHEMBL11372131 | 0.85 | ALDH1A1 (0.48) | KDM4EALDH1A1CYP19A1TBXAS1EGLN3 | |
| SCHEMBL11375080 | 0.84 | TBXAS1 (0.48) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289768-A | HYPOTENSIVE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |