Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372935 | 1.00 | RIPK1 (0.32) | RIPK1TAS1R3TAS1R1ALDH1A1CYP1A2 | |
| SCHEMBL11379705 | 0.94 | — | — | |
| SCHEMBL11379703 | 0.94 | — | — | |
| SCHEMBL11378760 | 0.93 | TRPA1 (0.34) | CYP1A2 | |
| SCHEMBL11378765 | 0.93 | TRPA1 (0.34) | CYP1A2 | |
| SCHEMBL11381411 | 0.88 | RIPK1 (0.32) | RIPK1 | |
| SCHEMBL11381422 | 0.88 | RIPK1 (0.32) | RIPK1 | |
| SCHEMBL11379612 | 0.85 | RIPK1 (0.34) | RIPK1 | |
| SCHEMBL11379615 | 0.85 | RIPK1 (0.34) | RIPK1 | |
| SCHEMBL11377605 | 0.84 | GPR84 (0.34) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243674-A | HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4143139-A | ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |