SCHEMBL11375286

SCHEMBL11375286

CCc1nncn1-c1ccc(O)cc1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 9/20 0.41
ESR2 Q92731 8/20 0.41
MAPT P10636 2/20 0.38
PTGS1 P23219 1/20 0.38
FGFR1 P11362 1/20 0.38
MAPK1 P28482 2/20 0.37
LMNA P02545 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MIF P14174 1/20 0.36
ENPP2 Q13822 1/20 0.34
MKNK1 Q9BUB5 1/20 0.34
MKNK2 Q9HBH9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11379919 0.86 ESR1 (0.43) ESR1ESR2MAPTPTGS1FGFR1
SCHEMBL11380491 0.76 MAPT (0.41) ESR1ESR2MAPTPTGS1FGFR1
SCHEMBL11390765 0.71 ALDH1A1 (0.47) ESR1ESR2MAPTPTGS1FGFR1
SCHEMBL11375358 0.71 PDE4A (0.51) ESR1ESR2PTGS1FGFR1LMNA
SCHEMBL12362835 0.70 PDE4A (0.52) ESR1ESR2MAPTPTGS1LMNA
Bromide SCHEMBL11377758 0.70 PDE4A (0.50) ESR1ESR2PTGS1FGFR1LMNA
SCHEMBL10627144 0.69 ESR1 (0.45) ESR1ESR2PTGS1
SCHEMBL11380717 0.69 ENPP2 (0.41) ESR1ESR2MAPTFGFR1KDM4E
SCHEMBL12362800 0.68 ESR1 (0.41) ESR1ESR2MAPTPTGS1MAPK1
SCHEMBL8529992 0.68 ALDH1A1 (0.51) MAPTLMNAALDH1A1GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4268680-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1981-05-19 US disclosed
US-4244964-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1981-01-13 US disclosed
US-4232034-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1980-11-04 US disclosed
US-4229581-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1980-10-21 US disclosed
US-4229460-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1980-10-21 US disclosed
US-4160841-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1979-07-10 US disclosed