Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11375011 | 0.83 | HTR7 (0.55) | HTR7BACE1BCHEABCB1ABCC1 | |
| SCHEMBL11371332 | 0.79 | HTR7 (0.51) | HTR7BACE1BCHEABCB1ABCC1 | |
| SCHEMBL11375428 | 0.76 | OPRD1 (0.41) | ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL11375425 | 0.76 | OPRD1 (0.41) | ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL11368370 | 0.74 | HTR7 (0.64) | HTR7BACE1ABCB1ABCC1CD274 | |
| SCHEMBL1111716 | 0.72 | HTR7 (0.66) | HTR7BACE1ABCB1ABCC1CD274 | |
| SCHEMBL11372233 | 0.70 | BACE1 (0.65) | HTR7BACE1BCHE | |
| SCHEMBL11384082 | 0.69 | MEN1 (0.62) | HTR7BACE1BCHEMLNRALDH1A1 | |
| SCHEMBL15937925 | 0.66 | HTR7 (1.00) | HTR7LMNADRD2DRD4DRD3 | |
| SCHEMBL10207059 | 0.66 | HTR7 (0.49) | HTR7ABCB1ABCC1CD274MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267318-A | 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof | G. D. SEARLE & CO. (US) | 1981-05-12 | — | — | US | disclosed |