Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.65 |
| ▸ | BCHE | P06276 | 12/20 | 0.57 |
| ▸ | ACHE | P22303 | 13/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11375011 | 0.86 | HTR7 (0.55) | BACE1BCHEACHEHTR7 | |
| SCHEMBL11381210 | 0.83 | BACE1 (0.59) | BACE1BCHEACHE | |
| SCHEMBL11381420 | 0.79 | HTR7 (0.58) | BACE1ACHEHTR7 | |
| SCHEMBL11376120 | 0.78 | BACE1 (0.66) | BACE1BCHEACHE | |
| SCHEMBL11375582 | 0.75 | BACE1 (0.49) | BACE1BCHEACHE | |
| SCHEMBL11374561 | 0.75 | ACHE (0.67) | BACE1BCHEACHEHTR7 | |
| SCHEMBL11371346 | 0.75 | BACE1 (0.52) | BACE1BCHEACHEHTR7 | |
| SCHEMBL11375433 | 0.70 | HTR7 (0.48) | BACE1BCHEHTR7 | |
| SCHEMBL15938028 | 0.69 | HTR7 (1.00) | HTR7 | |
| SCHEMBL11372229 | 0.69 | BACE1 (0.56) | BACE1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267318-A | 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof | G. D. SEARLE & CO. (US) | 1981-05-12 | — | — | US | disclosed |