Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11351100 | 0.86 | AKR1B1 (0.35) | AKR1B1 | |
| SCHEMBL11355290 | 0.76 | AKR1B10 (0.39) | AKR1B1 | |
| SCHEMBL6583197 | 0.70 | AKR1B1 (0.45) | AKR1B1 | |
| SCHEMBL11472424 | 0.68 | KDM1A (0.42) | — | |
| SCHEMBL6582062 | 0.68 | AKR1B1 (0.41) | AKR1B1 | |
| SCHEMBL11367422 | 0.66 | LDHA (0.37) | — | |
| SCHEMBL11353054 | 0.65 | AKR1B10 (0.39) | AKR1B1 | |
| SCHEMBL17606651 | 0.65 | LMNA (0.37) | — | |
| SCHEMBL11372831 | 0.65 | AKR1B1 (0.58) | AKR1B1 | |
| SCHEMBL11342636 | 0.64 | AKR1B1 (0.50) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4305877-A | ALDOSE REDUCTASE ENZYME INHIBITOR FOR TREATMENT OF CHRONIC DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4200642-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1980-04-29 | — | — | US | disclosed |