Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372831 | 0.83 | AKR1B1 (0.58) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL11353054 | 0.83 | AKR1B10 (0.39) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL11367422 | 0.80 | LDHA (0.37) | — | |
| SCHEMBL11472424 | 0.78 | KDM1A (0.42) | — | |
| SCHEMBL11351100 | 0.78 | AKR1B1 (0.35) | AKR1B1 | |
| SCHEMBL11377797 | 0.76 | AKR1B1 (0.36) | AKR1B1 | |
| SCHEMBL17606651 | 0.75 | LMNA (0.37) | MAPT | |
| SCHEMBL11352954 | 0.74 | VHL (0.39) | — | |
| SCHEMBL10921763 | 0.73 | AKR1B1 (0.71) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL10923913 | 0.73 | AKR1B1 (0.71) | AKR1B10MAPTAKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4305877-A | ALDOSE REDUCTASE ENZYME INHIBITOR FOR TREATMENT OF CHRONIC DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4267342-A | INHIBITORS OF OXIDOREDUCTASE ENZYMES; NERVOUS SYSTEM DISORDERS AND VISION DEFECTS CAUSED BY DIABETES | PFIZER INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4200642-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1980-04-29 | — | — | US | disclosed |