Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | UBE2N | P61088 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387907 | 0.85 | PDE1A (0.74) | ADORA2BSMN1; SMN2RXFP1ALDH1A1TSHR | |
| SCHEMBL11393503 | 0.85 | ADORA2B (0.63) | ADORA2BSMN1; SMN2RXFP1ALDH1A1TSHR | |
| SCHEMBL11386372 | 0.83 | SMN1; SMN2 (0.65) | ADORA2BSMN1; SMN2RXFP1ALDH1A1TSHR | |
| SCHEMBL1944405 | 0.83 | ADORA2B (1.00) | ADORA2BSMN1; SMN2RXFP1ALDH1A1TSHR | |
| SCHEMBL17786242 | 0.82 | ALDH1A1 (1.00) | ADORA2BSMN1; SMN2RXFP1ALDH1A1TSHR | |
| SCHEMBL11374923 | 0.81 | ADORA2B (0.62) | ADORA2BSMN1; SMN2RXFP1LMNAMAPK1 | |
| SCHEMBL19036787 | 0.80 | ADORA2B (0.69) | ADORA2BSMN1; SMN2RXFP1ALDH1A1LMNA | |
| SCHEMBL11380544 | 0.79 | ADORA2B (0.59) | ADORA2BSMN1; SMN2RXFP1LMNAMAPT | |
| SCHEMBL7459561 | 0.79 | POLB (0.65) | ADORA2BSMN1; SMN2RXFP1ALDH1A1TSHR | |
| SCHEMBL13659055 | 0.78 | SMN1; SMN2 (0.66) | ADORA2BSMN1; SMN2RXFP1CASP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4061753-A | Treating psoriasis with transient pro-drug forms of xanthine derivatives | INTERX RESEARCH CORPORATION (US) | 1977-12-06 | — | — | US | claimed |
| US-4275064-A | Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents | INTERX RESEARCH CORPORATION (US) | 1981-06-23 | — | — | US | disclosed |
| US-4061753-A | Treating psoriasis with transient pro-drug forms of xanthine derivatives | INTERX RESEARCH CORPORATION (US) | 1977-12-06 | — | — | US | disclosed |