Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPM1 | P06748 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11386043 | 0.89 | CYP19A1 (0.45) | CYP19A1LMNAHTTKMT2AMEN1 | |
| SCHEMBL6755431 | 0.87 | CYP19A1 (0.56) | CYP19A1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL11387115 | 0.83 | ALDH1A1 (0.58) | CYP19A1LMNAHTTMAPTNPSR1 | |
| SCHEMBL11382536 | 0.82 | HDAC6 (0.54) | CYP19A1LMNAMAPTNPSR1ALDH1A1 | |
| Fumaric Acid SCHEMBL11386887 | 0.81 | LMNA (0.42) | CYP19A1LMNAHTTMAPTNPSR1 | |
| SCHEMBL11382798 | 0.81 | HDAC6 (0.51) | CYP19A1LMNAALDH1A1ADRA2AADRA2B | |
| SCHEMBL11377416 | 0.79 | CYP19A1 (0.41) | CYP19A1KMT2AADRA2AADRA2BADRA2C | |
| SCHEMBL11375809 | 0.79 | HDAC6 (0.59) | CYP19A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL11376219 | 0.77 | HDAC6 (0.54) | CYP19A1HTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL11376099 | 0.77 | HDAC6 (0.54) | CYP19A1MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273782-A | FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |