Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSH | P09668 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255838 | 0.87 | MAPT (0.51) | GPR35CTSBCTSHMAPTALOX12 | |
| SCHEMBL11375997 | 0.84 | GPR35 (0.47) | GPR35CTSBCTSHMAPTALOX12 | |
| SCHEMBL9198198 | 0.84 | GPR35 (0.67) | GPR35CTSBMAPTALOX12CRHBP | |
| SCHEMBL29490141 | 0.84 | GPR35 (0.67) | GPR35CTSBMAPTALOX12CRHBP | |
| SCHEMBL11220965 | 0.81 | MAPT (0.51) | MAPTSIRT6POLBCYP3A4TSHR | |
| SCHEMBL11373753 | 0.80 | GPR35 (0.46) | GPR35CTSBCTSHMAPTALOX12 | |
| SCHEMBL11224373 | 0.78 | MAPT (0.47) | MAPTPOLBABCC1ALDH1A1KDM4E | |
| SCHEMBL11375180 | 0.77 | QDPR (0.56) | GPR35MAPTALOX12CRHBPCRHR2 | |
| SCHEMBL29878908 | 0.76 | CRHBP (0.68) | GPR35CTSBMAPTALOX12CRHBP | |
| SCHEMBL5595131 | 0.76 | CRHBP (0.68) | GPR35CTSBMAPTALOX12CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297363-A | 2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |