SCHEMBL1138565

SCHEMBL1138565

Nc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)nc1N

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.64
MTOR P42345 2/20 0.64
ALDH1A1 P00352 2/20 0.64
TP53 P04637 2/20 0.64
THRB P10828 1/20 0.64
MDM2 Q00987 1/20 0.64
NCOA1 Q15788 1/20 0.64
NCOA3 Q9Y6Q9 1/20 0.64
GMNN O75496 1/20 0.64
NFKB1 P19838 1/20 0.64
DNMT1 P26358 1/20 0.64
THPO P40225 1/20 0.64
HTT P42858 1/20 0.64
RAB9A P51151 1/20 0.64
BLM P54132 1/20 0.64
HBB P68871 1/20 0.64
PMP22 Q01453 1/20 0.64
MAPT P10636 2/20 0.54
CDA P32320 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1138566 1.00 LMNA (0.64) LMNAMTORALDH1A1TP53THRB
SCHEMBL2583058 0.88 LMNA (0.51) LMNAMTORALDH1A1TP53THRB
SCHEMBL10890255 0.88 PDE2A (0.52) LMNAMTORALDH1A1TP53THRB
SCHEMBL10890263 0.88 PDE2A (0.52) LMNAMTORALDH1A1TP53THRB
SCHEMBL1138717 0.88 LMNA (0.63) LMNAMTORALDH1A1TP53THRB
SCHEMBL1138719 0.88 LMNA (0.63) LMNAMTORALDH1A1TP53THRB
SCHEMBL4286246 0.87 LMNA (0.62) LMNAMTORALDH1A1TP53THRB
SCHEMBL770116 0.87 LMNA (0.62) LMNAMTORALDH1A1TP53THRB
SCHEMBL9690202 0.87 LMNA (0.62) LMNAMTORALDH1A1TP53THRB
SCHEMBL2584289 0.87 LMNA (0.62) LMNAMTORALDH1A1TP53THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260049338-A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS FACTOR BIOSCIENCE INC (US) 2026-02-19 US claimed
US-12384740-B2 Cationic lipids and transfection methods FACTOR BIOSCIENCE INC. (US) 2025-08-12 US claimed
US-12357664-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS (US) 2025-07-15 US claimed
CN-114450265-B Cationic lipids and uses thereof 菲克特生物科学股份有限公司 2024-12-24 CN claimed
US-20230373903-A1 CATIONIC LIPIDS AND TRANSFECTION METHODS FACTOR BIOSCIENCE INC. 2023-11-23 US claimed
US-11814333-B2 Cationic lipids and transfection methods FACTOR BIOSCIENCE INC. (US) 2023-11-14 US claimed
US-20230323399-A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS FACTOR BIOSCIENCE INC. 2023-10-12 US claimed
US-20230304044-A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS FACTOR BIOSCIENCE INC. 2023-09-28 US claimed
US-20230193207-A1 MESENCHYMAL STEM CELL THERAPIES FACTOR BIOSCIENCE INC. 2023-06-22 US claimed
US-20230193231-A1 ENGINEERED GENE-EDITING PROTEINS FACTOR BIOSCIENCE INC. 2023-06-22 US claimed
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-08-25 US claimed
US-6887707-B2 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-05-03 US claimed
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2003-06-26 US claimed
JP-2002509155-A 2002-03-26 JP claimed
EP-1047705-A2 NUCLEOBASE OLIGOMERS THE PERKIN-ELMER CORPORATION (US) 2000-11-02 EP claimed
US-6063628-A Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2000-05-16 US claimed
US-6054568-A Nucleobase oligomers THE PERKIN-ELMER CORPORATION (US) 2000-04-25 US claimed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP claimed
WO-1999036429-A2 NUCLEOBASE OLIGOMERS THE PERKIN-ELMER CORPORATION (US) 1999-07-22 WO claimed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030119764-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD LMNA 3576/4885MTOR 2746/4885ALDH1A1 1365/4885
US-20230323399-A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS NSUN3, STING1, NFATC1 LMNA 694/4885MTOR 3778/4885ALDH1A1 3071/4885
US-20230373903-A1 CATIONIC LIPIDS AND TRANSFECTION METHODS CETP, NPC1L1, NPC1 LMNA 264/4885MTOR 4508/4885ALDH1A1 4835/4885
US-12384740-B2 Cationic lipids and transfection methods CETP, NPC1L1, NPC1 LMNA 264/4885MTOR 4508/4885ALDH1A1 4835/4885
US-20230304044-A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS NSUN3, STING1, NFATC1 LMNA 694/4885MTOR 3778/4885ALDH1A1 3071/4885
US-11814333-B2 Cationic lipids and transfection methods CETP, NPC1L1, NPC1 LMNA 264/4885MTOR 4508/4885ALDH1A1 4835/4885
US-20260049338-A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS NSUN2, RNGTT, RNMT LMNA 333/4885MTOR 2014/4885ALDH1A1 3232/4885
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD LMNA 3576/4885MTOR 2746/4885ALDH1A1 1365/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.