Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115664 | 0.79 | HRH3 (0.42) | HRH3KCNJ1KCNH2 | |
| SCHEMBL113876 | 0.78 | SIGMAR1 (0.53) | HRH3SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL114612 | 0.78 | KCNH2 (0.55) | HRH3CYP1A2CYP2D6SIGMAR1KCNJ1 | |
| SCHEMBL115666 | 0.77 | GPR119 (0.44) | HTR1AHTR7 | |
| SCHEMBL23533516 | 0.74 | SIGMAR1 (0.49) | HRH3SIGMAR1KCNJ1KCNH2 | |
| SCHEMBL10294015 | 0.74 | HRH3 (0.64) | HRH3CYP1A2SIGMAR1 | |
| SCHEMBL12631545 | 0.73 | SLC6A3 (0.61) | SIGMAR1DRD2KCNH2HTR1A | |
| SCHEMBL20129356 | 0.71 | HRH3 (0.56) | HRH3SIGMAR1 | |
| SCHEMBL2447732 | 0.71 | DPP4 (0.39) | DRD2DRD4DRD3 | |
| SCHEMBL21550860 | 0.68 | TRPV6 (0.50) | HRH3SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |