⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184932 | 0.77 | TET2 (0.39) | — | |
| SCHEMBL28667481 | 0.77 | HMGCR (0.31) | — | |
| SCHEMBL14914212 | 0.74 | HMGCR (0.40) | — | |
| SCHEMBL662694 | 0.74 | — | — | |
| SCHEMBL28331383 | 0.73 | ALDH1A1 (0.41) | — | |
| SCHEMBL4574752 | 0.73 | ALDH1A1 (0.42) | — | |
| SCHEMBL468417 | 0.70 | — | — | |
| SCHEMBL13995531 | 0.69 | TRPA1 (0.38) | — | |
| SCHEMBL3697055 | 0.67 | HMGCR (0.41) | — | |
| SCHEMBL6857048 | 0.67 | CES1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12252511-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2025-03-18 | — | — | US | disclosed |
| US-20240116989-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE, INC. (US) | 2024-04-11 | — | — | US | disclosed |
| US-11739123-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| CN-110156874-B | Cyclic depsipeptide compounds | 恩库勒公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20220002347-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE, INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-11053284-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| EP-3578179-B1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20200347097-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| US-10689419-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3578179-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | Onkure, Inc. (US) | 2019-12-11 | — | — | EP | disclosed |
| US-20190177372-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2019-06-13 | — | — | US | disclosed |
| US-10100089-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2018-10-16 | — | — | US | disclosed |
| US-20170183382-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2017-06-29 | — | — | US | disclosed |
| EP-3148540-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | Onkure, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183897-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE, INC. (US) | 2015-12-03 | — | — | WO | disclosed |
| US-4257947-A | INTERMEDIATES FOR ANTIBACTERIAL CEPHALOSPORINS | SMITHKLINE CORPORATION (US) | 1981-03-24 | — | — | US | disclosed |
| US-4166816-A | CYCLIZATION | SMITHKLINE CORPORATION (US) | 1979-09-04 | — | — | US | disclosed |
| US-4103086-A | 8-Oxo-4-thia-1-azabicyclo (4.2.0)-oct-2-ene derivatives | SMITHKLINE CORPORATION (US) | 1978-07-25 | — | — | US | disclosed |
| US-4072674-A | FOR CEPHALOSPORIN CONGENERS | SMITHKLINE CORPORATION (US) | 1978-02-07 | — | — | US | disclosed |