Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646111 | 0.83 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2LMNAMAPTALOX12 | |
| SCHEMBL11393334 | 0.83 | MAPT (0.62) | GAAALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL11394247 | 0.82 | CETP (0.62) | GAAGFERALDH1A1LMNAMAPT | |
| SCHEMBL6714846 | 0.81 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2LMNAMAPTALOX12 | |
| SCHEMBL11100857 | 0.81 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2LMNAMAPTALOX12 | |
| SCHEMBL6739807 | 0.80 | AKR1C3 (0.63) | GAAGFERALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11403721 | 0.78 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2LMNAMAPTSIGMAR1 | |
| SCHEMBL1124210 | 0.76 | AKR1C3 (0.58) | GAAGFERALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1124075 | 0.75 | MAPT (0.56) | GAAALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL30407444 | 0.74 | HTR3E (0.69) | ALDH1A1SMN1; SMN2LMNAMAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | claimed |