Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 9/20 | 0.62 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11393334 | 0.87 | MAPT (0.62) | CETPALDH1A1GAAMAPTKDM4E | |
| SCHEMBL11393145 | 0.83 | MEN1 (0.61) | ALDH1A1GAAGFERMAPTKDM4E | |
| SCHEMBL11394205 | 0.82 | GAA (0.58) | ALDH1A1GAAGFERMAPTLMNA | |
| SCHEMBL11396473 | 0.79 | MAPT (0.65) | ALDH1A1GAAMAPTKDM4ENPC1 | |
| SCHEMBL11396110 | 0.79 | KDM4E (0.61) | DRD4ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL29998630 | 0.77 | HTR3E (0.70) | DRD4ALDH1A1GAAGFERMAPT | |
| SCHEMBL870704 | 0.77 | HTR3E (0.70) | DRD4ALDH1A1GAAGFERMAPT | |
| SCHEMBL23657514 | 0.76 | KMT2A (0.71) | CETPDRD4ALDH1A1GAAGFER | |
| SCHEMBL1124075 | 0.75 | MAPT (0.56) | CETPDRD4ALDH1A1GAAMAPT | |
| SCHEMBL11211440 | 0.75 | HSD17B10 (0.43) | CETPALDH1A1GAAGFERMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | claimed |