Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.64 |
| ▸ | CCR5 | P51681 | 4/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2405257 | 0.93 | CCR5 (0.62) | SIGMAR1CCR5EPHX2PTGDR2SMN1; SMN2 | |
| SCHEMBL5860907 | 0.86 | CCR5 (0.56) | SIGMAR1CCR5EPHX2PTGDR2SMN1; SMN2 | |
| SCHEMBL31473504 | 0.86 | CCR5 (0.56) | SIGMAR1CCR5EPHX2PTGDR2SMN1; SMN2 | |
| SCHEMBL14297341 | 0.84 | NPC1 (0.55) | SIGMAR1CCR5MEN1KMT2ANPC1 | |
| SCHEMBL3528763 | 0.83 | SIGMAR1 (0.72) | SIGMAR1CCR5EPHX2MEN1KMT2A | |
| SCHEMBL2575803 | 0.82 | MEN1 (0.51) | SIGMAR1CCR5MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11534945 | 0.82 | SIGMAR1 (0.70) | SIGMAR1CCR5EPHX2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4283829 | 0.82 | CCR5 (0.62) | SIGMAR1CCR5EPHX2KMT2AALDH1A1 | |
| SCHEMBL5862792 | 0.79 | KCNH2 (0.72) | SIGMAR1CCR5 | |
| SCHEMBL15962426 | 0.78 | SIGMAR1 (1.00) | SIGMAR1MEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4248877-A | ANTIDEPRESSANTS, ANALGESICS, ANTIMIGRAINE AGENTS | SANDOZ LTD. (CH) | 1981-02-03 | — | — | US | disclosed |
| US-4178377-A | USE TO TREAT PAIN AND MIGRAINE | SANDOZ LTD. (CH) | 1979-12-11 | — | — | US | disclosed |