Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.38 |
| ▸ | HPGD | P15428 | 7/20 | 0.38 |
| ▸ | POLB | P06746 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11404946 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL11323918 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL10365746 | 0.74 | ACHE (0.64) | LMNAKMT2AMAPTCYP2C19MEN1 | |
| SCHEMBL11312704 | 0.72 | ACHE (0.42) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL11319088 | 0.72 | IDO1 (0.33) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL10999537 | 0.71 | MAPT (0.38) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL11001538 | 0.71 | ALDH1A1 (0.35) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL11361223 | 0.69 | ALDH1A1 (0.33) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL11226041 | 0.69 | PSMB5 (0.38) | SMN1; SMN2LMNAALDH1A1HPGDPOLB | |
| SCHEMBL11226037 | 0.69 | PSMB5 (0.38) | SMN1; SMN2LMNAALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293697-A | ANTIHISTAMINES | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |