Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5944481 | 0.75 | ACHE (0.42) | ACHELMNAIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26422119 | 0.73 | ACHE (0.42) | ACHELMNAALDH1A1BLMSMN1; SMN2 | |
| SCHEMBL5436496 | 0.72 | APOBEC3A (0.50) | ACHELMNAALDH1A1BLMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11681238 | 0.71 | GAA (0.40) | PSMD14RAD52ACHELMNALOXL2 | |
| Water SCHEMBL8385260 | 0.70 | APOBEC3A (0.48) | ACHELMNAALDH1A1BLMSMN1; SMN2 | |
| SCHEMBL18644113 | 0.70 | CA1 (0.50) | ACHEAOC3IDO1ALDH1A1TAAR1 | |
| SCHEMBL11775956 | 0.68 | — | — | |
| SCHEMBL5712018 | 0.68 | ALDH1A1 (0.47) | LMNAALDH1A1SMN1; SMN2 | |
| Alcohol SCHEMBL28041790 | 0.67 | ACHE (0.53) | ACHELMNAIDO1LOXL2ALDH1A1 | |
| Ethylamine SCHEMBL27972784 | 0.64 | LOXL2 (0.58) | ACHELMNAAOC3IDO1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028696-A1 | Use of quaternary ammonium salts as latent catalysts in coating compositions based on polyurethane or epoxy resin prepolymers, coating compositions containing these catalysts and a process for preparing these coatings | BAYER AG (DE) | 1981-05-20 | — | — | EP | disclosed |