Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11399726 | 1.00 | OPRM1 (0.70) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| SCHEMBL8396856 | 0.96 | OPRD1 (0.76) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| SCHEMBL8396855 | 0.96 | OPRD1 (0.76) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| SCHEMBL11398571 | 0.96 | OPRD1 (0.76) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL7484569 | 0.95 | OPRD1 (0.74) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL7484574 | 0.95 | OPRD1 (0.74) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| SCHEMBL7486453 | 0.88 | OPRM1 (0.60) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| SCHEMBL7486456 | 0.88 | OPRM1 (0.60) | OPRM1OPRD1OPRK1SLC6A4SLC6A2 | |
| SCHEMBL11395004 | 0.87 | OPRK1 (0.92) | OPRM1OPRD1OPRK1 | |
| SCHEMBL11395009 | 0.87 | OPRK1 (0.92) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4301290-A | 4-PHENYL-DECAHYDROISOQUINOLINE DERIVATIVES FOR USE AS ANALGESICS, ANTIDEPRESSANTS, TRANQUILIZERS, SLEEP INDUCERS | SANDOZ LTD. (CH) | 1981-11-17 | — | — | US | disclosed |