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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL11416635

C[C@@H](OC(=O)[C@@H](N)CCCN)[C@H](N)C(=O)O.N=C(N)NCC(O)C[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCC[C@H](N)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 17/20 0.45
▸ NPY1R P25929 10/20 0.45
▸ NPY5R Q15761 8/20 0.43
▸ NPY2R P49146 6/20 0.43
▸ SLC7A5 Q01650 1/20 0.36
▸ THRB P10828 1/20 0.36
▸ LNPEP Q9UIQ6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL11412240 0.98 NPY4R (0.45) NPY4RNPY1RNPY5RNPY2RSLC7A5
Tyrosine SCHEMBL11101797 0.87 NPY4R (0.51) NPY4RNPY1RNPY5RNPY2RSLC7A5
Tyrosine SCHEMBL18042254 0.82 NPY4R (0.44) NPY4RNPY1RNPY5RNPY2R
Tyrosine SCHEMBL10613813 0.82 NPY4R (0.58) NPY4RNPY1RNPY5RNPY2RSLC7A5
Arginine SCHEMBL258862 0.81 NPY4R (0.42) NPY4RNPY1RNPY5RNPY2RTHRB
Arginine SCHEMBL6130138 0.81 GSR (0.46) NPY4RNPY1RNPY5RNPY2RTHRB
Tyrosine SCHEMBL10610673 0.81 SLC7A5 (0.55) NPY4RNPY1RNPY5RNPY2RSLC7A5
Tyrosine SCHEMBL18042256 0.81 NPY4R (0.40) NPY4RNPY1RNPY5RNPY2R
Tyrosine SCHEMBL18042253 0.80 NPY4R (0.40) NPY4RNPY1RNPY5RNPY2R
Tyrosine SCHEMBL18042245 0.80 NPY4R (0.40) NPY4RNPY1RNPY5RNPY2RLNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4221705-A ANTIBIOTIC K 582 M-A AND M-B KAKENYAKU KAKO CO., LTD. (JP) 1980-09-09 — — US claimed
US-4221705-A ANTIBIOTIC K 582 M-A AND M-B KAKENYAKU KAKO CO., LTD. (JP) 1980-09-09 — — US disclosed