Sugi Predict

Sugi Predict / Compounds / SCHEMBL114189

SCHEMBL114189

SCHEMBL114189

CC(=O)Nc1ccc(N)cn1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PTK2 Q05397 1/20 0.62
▸ CYP1A2 P05177 1/20 0.56
▸ GAA P10253 1/20 0.56
▸ PTGS1 P23219 3/20 0.54
▸ KMT2A Q03164 1/20 0.48
▸ MAPT P10636 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.46
▸ HSP90AA1 P07900 1/20 0.46
▸ HSP90AB1 P08238 1/20 0.46
▸ USP7 Q93009 1/20 0.46
▸ NSD2 O96028 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.44
▸ PIK3CA P42336 1/20 0.43
▸ TDO2 P48775 1/20 0.43
▸ PKM P14618 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29657055 1.00 PTK2 (0.62) PTK2CYP1A2GAAPTGS1KMT2A
Alcohol SCHEMBL29043050 0.93 PTK2 (0.56) PTK2CYP1A2GAAPTGS1KMT2A
SCHEMBL27582415 0.83 PTK2 (0.53) PTK2CYP1A2GAAPTGS1KMT2A
SCHEMBL477342 0.82 PTGS1 (0.55) PTK2PTGS1MAPTRAB9AL3MBTL1
SCHEMBL28863251 0.82 CDK8 (0.53) PTK2CYP1A2GAAPTGS1KMT2A
SCHEMBL29996275 0.82 CDK8 (0.53) PTK2CYP1A2GAAPTGS1KMT2A
SCHEMBL13403361 0.81 PTGS1 (0.51) PTK2PTGS1KMT2AMAPTRAB9A
SCHEMBL22557436 0.80 HSD17B10 (0.54) PTGS1MAPTRAB9AL3MBTL1TDP1
SCHEMBL30753588 0.80 HSD17B10 (0.54) PTGS1MAPTRAB9AL3MBTL1TDP1
SCHEMBL1163357 0.80 PTGS1 (0.54) PTK2CYP1A2PTGS1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116514576-B Gypsum board loaded with formaldehyde scavenger and preparation method thereof 杰森石膏板（嘉兴）有限公司 2023-10-31 — — CN claimed
CN-116514576-A Gypsum board loaded with formaldehyde scavenger and preparation method thereof 杰森石膏板（嘉兴）有限公司 2023-08-01 — — CN claimed
CN-107759514-A A kind of preparation method of the fluorine pyridine of 2 amino 5 苏州盖德精细材料有限公司 2018-03-06 — — CN claimed
EP-1937652-B1 PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS AVENTIS PHARMA INC (US) 2014-07-30 — — EP claimed
US-8354444-B2 Substituted pyrrolidine-2-carboxamides HOFFMANN-LA ROCHE INC. (US) 2013-01-15 — — US claimed
EP-2340021-B1 SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES HOFFMANN LA ROCHE (CH) 2012-11-07 — — EP claimed
US-8202863-B2 2-Phenyl-pyrimidine-5-carboxylic acid benzylamide; to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease AVENTIS PHARMACEUTICALS INC. (US) 2012-06-19 — — US claimed
US-20100152190-A1 Substituted Pyrrolidine-2-Carboxamides F. HOFFMANN-LA ROCHE AG (CH) 2010-06-17 — — US claimed
WO-2010031713-A1 SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES F. HOFFMANN-LA ROCHE AG (CH) 2010-03-25 — — WO claimed
US-20100075948-A1 Substituted Pyrrolidine-2-Carboxamides DING QINGJIE 2010-03-25 — — US claimed
US-20080227782-A1 PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS AVENTIS PHARMACEUTICALS INC (US) 2008-09-18 — — US claimed
EP-1937652-A1 PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS Aventis Pharmaceuticals Inc. (US) 2008-07-02 — — EP claimed
WO-2007041634-A1 PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2007-04-12 — — WO claimed
US-20060276453-A1 Anti-Cytokine Heterocyclic Compounds BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2006-12-07 — — US claimed
US-20060135589-A1 1h-Indazole-3-carboxamide compounds as cyclin dependent kinase (cdk) inhibitors ASTEX TECHNOLOGY, INC. (GB) 2006-06-22 — — US claimed
JP-2006500348-A — — 2006-01-05 — — JP claimed
EP-1534685-A1 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS CYCLIN DEPENDENT KINASES (CDK) INHIBITORS Astex Technology Limited (GB) 2005-06-01 — — EP claimed
WO-2004014864-A1 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS CYCLIN DEPENDENT KINASES (CDK) INHIBITORS ASTEX TECHNOLOGY LIMITED (GB) 2004-02-19 — — WO claimed
EP-4574150-A2 A MAGL INHIBITOR H. Lundbeck A/S (DK) 2025-06-25 — — EP disclosed
EP-0503627-A1 Aminopyridine compounds THE GREEN CROSS CORPORATION (JP) 1992-09-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227782-A1 PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS HRH2, HRH1, LTC4S PTK2 4035/4885CYP1A2 409/4885GAA 1391/4885
US-20100152190-A1 Substituted Pyrrolidine-2-Carboxamides ARG2, CCNY, PYCR1 PTK2 4517/4885CYP1A2 730/4885GAA 2654/4885
US-20060276453-A1 Anti-Cytokine Heterocyclic Compounds MAPKAPK2, MAP4K2, MAP3K2 PTK2 311/4885CYP1A2 3664/4885GAA 2842/4885
US-20100075948-A1 Substituted Pyrrolidine-2-Carboxamides ARG2, CCNY, PYCR1 PTK2 4517/4885CYP1A2 730/4885GAA 2654/4885
US-20060135589-A1 1h-Indazole-3-carboxamide compounds as cyclin dependent kinase (cdk) inhibitors CCNC, CDK1, CDK7 PTK2 648/4885CYP1A2 1977/4885GAA 4491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.