Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 4/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11428696 | 0.89 | HSD11B1 (0.50) | HSD11B1EIF4EPTGER1PTGER3PTGER2 | |
| SCHEMBL11435056 | 0.85 | HSD11B1 (0.42) | HSD11B1EIF4EBRD4PTGER1PTGER3 | |
| SCHEMBL11434888 | 0.84 | AHR (0.41) | HSD11B1BRD4KDM4EAHRAKR1C3 | |
| SCHEMBL11426898 | 0.83 | EGFR (0.43) | BRD4KDM4EHTTMAOB | |
| SCHEMBL11552820 | 0.82 | BRD4 (0.46) | HSD11B1BRD4KDM4ENPC1RAB9A | |
| SCHEMBL11439626 | 0.82 | ALKBH3 (0.43) | HSD11B1AHRAKR1C2ALKBH3POLB | |
| SCHEMBL11551075 | 0.81 | BRD4 (0.45) | BRD4NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL11551750 | 0.81 | BRD4 (0.47) | BRD4KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11429789 | 0.80 | EGFR (0.44) | HSD11B1KDM4EAHRMAOB | |
| SCHEMBL3749078 | 0.78 | AHR (0.54) | HSD11B1EIF4EPTGER1PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4235619-A | USING 3-PHENYL-4(1H)-PYRIDONES OR PYRIDINETHIONES | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4152136-A | HERBICIDES | ELI LILLY AND COMPANY (US) | 1979-05-01 | — | — | US | disclosed |