Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 5/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11428176 | 0.84 | HSD11B1 (0.45) | AHRAKR1C3AKR1C2ALKBH3HSD11B1 | |
| SCHEMBL11435056 | 0.83 | HSD11B1 (0.42) | AHRAKR1C3AKR1C2ALKBH3HSD11B1 | |
| SCHEMBL11439626 | 0.82 | ALKBH3 (0.43) | AHRAKR1C2ALKBH3HSD11B1MAPT | |
| SCHEMBL11428912 | 0.81 | BRD4 (0.46) | BRD4KMT2AMAPTKDM4EMEN1 | |
| SCHEMBL11429789 | 0.81 | EGFR (0.44) | AHRHSD11B1PGRKMT2AKDM4E | |
| SCHEMBL11428696 | 0.81 | HSD11B1 (0.50) | AHRHSD11B1PGRMAPTKDM4E | |
| SCHEMBL11439462 | 0.78 | AHR (0.38) | AHRALKBH3HSD11B1KMT2AMEN1 | |
| SCHEMBL11436424 | 0.75 | RORB (0.44) | AKR1C3AKR1C2PGRMAPTALOX12 | |
| SCHEMBL11428824 | 0.73 | KCNA3 (0.41) | PGRMAPTKDM4EALOX12PTGS2 | |
| SCHEMBL11431671 | 0.69 | EGFR (0.50) | PGRKMT2AKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4235619-A | USING 3-PHENYL-4(1H)-PYRIDONES OR PYRIDINETHIONES | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4152136-A | HERBICIDES | ELI LILLY AND COMPANY (US) | 1979-05-01 | — | — | US | disclosed |