Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202228 | 0.86 | KDM4E (0.57) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL14899552 | 0.83 | KDM4E (0.49) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL30184227 | 0.75 | CYP2D6 (0.55) | KDM4EHSD17B10ALDH1A1MAPTMAOA | |
| SCHEMBL10515648 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL1143122 | 0.74 | KDM4E (0.46) | KDM4EHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL6022766 | 0.72 | KMT2A (0.59) | KDM4EKMT2AALDH1A1HPGDGAA | |
| SCHEMBL6022769 | 0.72 | KMT2A (0.59) | KDM4EKMT2AALDH1A1HPGDGAA | |
| SCHEMBL1675661 | 0.71 | ALDH1A1 (0.50) | KDM4EKMT2AALDH1A1HPGDMAPT | |
| SCHEMBL4123425 | 0.70 | TSHR (0.43) | KDM4EKMT2AALDH1A1HPGDMAPT | |
| SCHEMBL2333730 | 0.70 | HTT (0.59) | KDM4EKMT2AALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459560-B1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MERCK SHARP & DOHME (NL) | 2015-08-19 | — | — | EP | disclosed |
| EP-2459560-B1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MERCK SHARP & DOHME (NL) | 2015-08-19 | — | — | EP | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8431564-B2 | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines | MERCK SHARP & DOHME B.V. (NL) | 2013-04-30 | — | — | US | disclosed |
| US-8394789-B2 | (Dihydro)pyrrolo[2,1-α]isoquinolines | MSD OSS B.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| US-8394789-B2 | (Dihydro)pyrrolo[2,1-α]isoquinolines | MSD OSS B.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| US-8394789-B2 | (Dihydro)pyrrolo[2,1-α]isoquinolines | MSD OSS B.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| EP-2459560-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | MSD Oss B.V. (NL) | 2012-06-06 | — | — | EP | disclosed |
| EP-2252611-B1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | ORGANON NV (NL) | 2011-10-05 | — | — | EP | disclosed |
| EP-2252611-B1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | ORGANON NV (NL) | 2011-10-05 | — | — | EP | disclosed |
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-17 | — | — | US | disclosed |
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-17 | — | — | US | disclosed |
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-17 | — | — | US | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
| WO-2011012600-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011012600-A1 | RING-ANNULATED DIHYDROPYRROLO[2,L-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |
| EP-2252611-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. Organon (NL) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009098283-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009098283-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | PKD2, PKD1, CATSPER1 | KDM4E 2134/4885HSD17B10 747/4885KMT2A 1445/4885 |
| US-20110028450-A1 | Ring-annulated dihydropyrrolo[2,1-alpha]isoquinolines | CATSPER1, QDPR, NASP | KDM4E 2195/4885HSD17B10 851/4885KMT2A 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.