Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | KLK1 | P06870 | 2/20 | 0.37 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11438683 | 0.91 | AURKA (0.41) | AURKAAURKBMEN1KMT2AMAP1LC3B | |
| SCHEMBL11438825 | 0.89 | MEN1 (0.41) | AURKAAURKBMEN1KMT2AMAP1LC3B | |
| SCHEMBL11439444 | 0.87 | TTR (0.43) | AURKAAURKBMEN1KMT2AKDM4E | |
| SCHEMBL11430407 | 0.85 | KCNMA1 (0.47) | MEN1KMT2AKDM4ESMN1; SMN2GAA | |
| SCHEMBL11438814 | 0.84 | MPL (0.46) | AURKAAURKBMEN1KMT2AKDM4E | |
| SCHEMBL11433192 | 0.84 | AURKA (0.43) | AURKAAURKBMEN1KMT2APLG | |
| SCHEMBL11423179 | 0.83 | KCNMA1 (0.49) | MEN1KMT2AKDM4ERAB9ANPC1 | |
| SCHEMBL11441473 | 0.83 | AURKA (0.50) | AURKAAURKBMEN1KMT2AMAP1LC3B | |
| SCHEMBL11435238 | 0.83 | AURKA (0.44) | AURKAAURKBMEN1KMT2ARAB9A | |
| SCHEMBL11426181 | 0.83 | LMNA (0.47) | MEN1KMT2AMAP1LC3BPLGKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216165-A | Amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |