Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5857803 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL9046912 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL9313048 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL9045211 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL10416126 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL10553544 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL9546230 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL9423301 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL5857804 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT | |
| SCHEMBL8699325 | 1.00 | CTSL (0.31) | CTSLCTSSCTSKCTSBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421503-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12049649-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2024-07-30 | — | — | US | disclosed |
| US-20240141304-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2024-05-02 | — | — | US | disclosed |
| US-20210324347-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2021-10-21 | — | — | US | disclosed |
| US-11078466-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-20200172880-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2020-06-04 | — | — | US | disclosed |
| US-10597641-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190256825-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2019-08-22 | — | — | US | disclosed |
| US-10329540-B2 | Ketoreductase polypeptides for the production of azetidinone | CODEXIS, INC. (US) | 2019-06-25 | — | — | US | disclosed |
| US-20170313992-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2017-11-02 | — | — | US | disclosed |
| US-5102877-A | Carbapenicillin antibiotics | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5075439-A | Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor | PFIZER INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0433759-A1 | 4-Substituted alkyl carbapenem antibiotics | Bristol-Myers Squibb Company (US) | 1991-06-26 | — | — | EP | disclosed |
| EP-0394991-A1 | 1-Azabicyclo(3.2.0)Hept-2-Ene-2-carboxylic acid compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |
| US-4895939-A | ANTIBIOTICS | BRISTOL-MYERS COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| US-4845210-A | Azetidinone derivatives and processes for production thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| US-4841043-A | Stereoselective synthesis of 1-β-alkyl carbapenem antibiotic intermediates | BRISTOL-MYERS COMPANY (US) | 1989-06-20 | — | — | US | disclosed |
| US-4772683-A | SILYLATION, AZETIDONE THIOLESTERS | BRISTOL-MYERS COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0232786-A1 | Heterocyclic compounds and their production | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-08-19 | — | — | EP | disclosed |
| EP-0171064-A1 | Azetidinone derivative and processes for production thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-02-12 | — | — | EP | disclosed |