Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM2 | P50570 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 5/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495475 | 0.81 | KCNH2 (0.48) | DNM2KCNH2PDPK1PI4KAPI4K2B | |
| SCHEMBL1685607 | 0.79 | KCNH2 (0.52) | DNM2KCNH2ESR1PI4KAPI4K2B | |
| SCHEMBL2052342 | 0.77 | NOS2 (0.44) | KCNH2PDPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL24798597 | 0.73 | KCNH2 (0.46) | DNM2KCNH2NOS2CYP3A4PTGS2 | |
| SCHEMBL1444787 | 0.73 | KCNH2 (0.41) | DNM2KCNH2PDPK1PI4KAPI4K2B | |
| SCHEMBL11815923 | 0.73 | PTGS2 (0.42) | KCNH2ESR1LMNACYP3A4PTGS2 | |
| SCHEMBL1444830 | 0.73 | KCNH2 (0.41) | KCNH2PDPK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL12449394 | 0.71 | NOS2 (0.50) | PDPK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL11667016 | 0.70 | GAA (0.43) | KCNH2SMN1; SMN2 | |
| SCHEMBL4076540 | 0.70 | L3MBTL1 (0.42) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4269980-A | TRANQUILIZERS; ANTICONVULSANTS | AMERICAN CYANAMID COMPANY (US) | 1981-05-26 | — | — | US | disclosed |