Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.72 |
| ▸ | DHFR | P00374 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | CTSG | P08311 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813951 | 0.87 | PIK3CG (0.72) | PIK3CGDHFRALDH1A1KDM4EJAK2 | |
| SCHEMBL3748026 | 0.84 | PIK3CG (1.00) | PIK3CGMTORPIK3CAPIK3CBHDAC6 | |
| SCHEMBL4451767 | 0.80 | PIK3CG (0.68) | PIK3CGDHFRALDH1A1HPGDNOS1 | |
| SCHEMBL11446163 | 0.80 | ADK (0.67) | PIK3CGKDM4ECYP1A2CYP2C9HPGD | |
| SCHEMBL3736445 | 0.77 | PIK3CG (1.00) | PIK3CGMTORPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3809859 | 0.75 | TLR9 (0.53) | PIK3CGALDH1A1GLAGAAMAPK1 | |
| SCHEMBL3746280 | 0.74 | PIK3CG (1.00) | PIK3CGDHFRALDH1A1KDM4EJAK2 | |
| SCHEMBL13040779 | 0.74 | NLRP3 (0.61) | PIK3CGDHFRALDH1A1KDM4EJAK2 | |
| Triamterene SCHEMBL40707 | 0.72 | ALDH1A1 (1.00) | PIK3CGDHFRALDH1A1KDM4EJAK2 | |
| SCHEMBL10894514 | 0.72 | ALDH1A1 (0.87) | PIK3CGDHFRALDH1A1KDM4EJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4187307-A | 4-AMINOPTERIDINES | ABBOTT LABORATORIES (US) | 1980-02-05 | — | — | US | disclosed |
| US-4183934-A | NONALIURETIC DIURETICS | ABBOTT LABORATORIES (US) | 1980-01-15 | — | — | US | disclosed |