Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | CETP | P11597 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446797 | 0.96 | ALDH1A1 (0.56) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL11445291 | 0.93 | TSHR (0.52) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL28256535 | 0.78 | CETP (0.77) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL28258088 | 0.78 | CETP (0.77) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL12323604 | 0.78 | CETP (0.77) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL535076 | 0.78 | KCNQ2 (0.44) | TSHRNPSR1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11445874 | 0.77 | ALDH1A1 (0.64) | USP2ALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL11446342 | 0.75 | SMN1; SMN2 (0.59) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL4223097 | 0.74 | HDAC1 (1.00) | TSHRHDAC3HDAC1HDAC2NPSR1 | |
| SCHEMBL8938751 | 0.74 | MAPT (0.47) | TSHRUSP2ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |