Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10546524 | 0.89 | L3MBTL1 (0.55) | SMN1; SMN2PLA2G1BATG4BLMNAPOLB | |
| SCHEMBL11445626 | 0.86 | ALDH1A1 (0.55) | SMN1; SMN2PLA2G1BATG4BALDH1A1POLB | |
| SCHEMBL11445134 | 0.85 | TP53 (0.54) | LMNAGAAALDH1A1POLBHPGD | |
| SCHEMBL11445874 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2LMNAALDH1A1HPGDMAPT | |
| SCHEMBL2269025 | 0.81 | MAPT (0.50) | SMN1; SMN2PLA2G1BATG4BLMNAGAA | |
| SCHEMBL11445179 | 0.81 | ALDH1A1 (0.64) | SMN1; SMN2LMNAALDH1A1NPSR1HPGD | |
| SCHEMBL11445531 | 0.80 | ALDH1A1 (0.67) | SMN1; SMN2LMNAGAAALDH1A1NPSR1 | |
| SCHEMBL14428453 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2PLA2G1BATG4BLMNAGAA | |
| SCHEMBL11445253 | 0.79 | KCNQ2 (0.65) | SMN1; SMN2LMNAGAAALDH1A1NPSR1 | |
| SCHEMBL11445291 | 0.78 | TSHR (0.52) | SMN1; SMN2LMNAGAAALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186199-A | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines | AMERICAN HOECHST CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |
| US-4182872-A | CORRESPONDING 4-CARBOBENZOXY COMPOUNDS, 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALIN-5(6H)-ONES, 2,3,4,4A,5,6-HEXAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALINES, HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-08 | — | — | US | disclosed |
| US-4182869-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-01-08 | — | — | US | disclosed |
| US-4138567-A | HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-02-06 | — | — | US | disclosed |
| US-4032639-A | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-06-28 | — | — | US | disclosed |