SCHEMBL11445652

SCHEMBL11445652

Cc1cc(N)ccc1-n1c(C)nc2ccccc2c1=O

nearest known ligand 0.76

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.76
L3MBTL1 Q9Y468 3/20 0.70
LMNA P02545 2/20 0.70
GLA P06280 1/20 0.61
SMN1; SMN2 Q16637 3/20 0.58
MAPT P10636 2/20 0.58
KDM4E B2RXH2 2/20 0.58
POLB P06746 3/20 0.58
HSD17B10 Q99714 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
TSHR P16473 1/20 0.52
PDE4D Q08499 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1551501 0.86 ALDH1A1 (1.00) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
SCHEMBL11445400 0.85 ALDH1A1 (0.78) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
SCHEMBL29453217 0.84 PDE4D (0.72) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
SCHEMBL9340028 0.84 ALDH1A1 (0.70) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
SCHEMBL11786525 0.84 PDE4D (0.72) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
Methaqualone SCHEMBL20471677 0.83 ALDH1A1 (1.00) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
Methaqualone SCHEMBL29355239 0.83 ALDH1A1 (1.00) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
Methaqualone SCHEMBL43892 0.83 ALDH1A1 (1.00) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
Methaqualone SCHEMBL29386732 0.83 ALDH1A1 (1.00) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2
Methaqualone SCHEMBL29849847 0.81 ALDH1A1 (0.97) ALDH1A1L3MBTL1LMNAGLASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4053459-A ANTIBODY SPECIFIC TO METHAQUALONE AND ITS METABOLITES HOFFMANN-LA ROCHE INC. (US) 1977-10-11 US claimed
US-4182879-A N-[3-methyl-4-(2-methyl-4-oxo-3,4-dihydro-quinazolin-3-yl)phenyl]succinamic acid HOFFMANN-LA ROCHE INC. (US) 1980-01-08 US disclosed
US-4107285-A LABELLING, ANTIBODIES HOFFMANN-LA ROCHE INC. (US) 1978-08-15 US disclosed
US-4053459-A ANTIBODY SPECIFIC TO METHAQUALONE AND ITS METABOLITES HOFFMANN-LA ROCHE INC. (US) 1977-10-11 US disclosed