Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methaqualone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.97 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methaqualone SCHEMBL29849847 | 1.00 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL43892 | 0.98 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29355239 | 0.98 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29386732 | 0.98 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL20471677 | 0.98 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29064194 | 0.95 | ALDH1A1 (0.94) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL16596956 | 0.84 | L3MBTL1 (0.77) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL1551501 | 0.84 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL19612477 | 0.84 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL1551591 | 0.83 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1LMNANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117842110-A | Vehicle-mounted satellite positioning system speed delay interval cycle number measurement method | 湖南工业大学 | 2024-04-09 | — | — | CN | claimed |
| CN-112721672-B | Leakage magnetic field regulation and control system and method for dynamic wireless power supply system | 哈尔滨宇龙自动化有限公司 | 2023-10-20 | — | — | CN | claimed |
| CN-114429431-B | Identification method and system for converting image from underwater to air | 西南科技大学 | 2022-06-21 | — | — | CN | claimed |
| CN-114429431-A | Identification method and system for converting image from underwater to air | 西南科技大学 | 2022-05-03 | — | — | CN | claimed |
| CN-105553460-A | Fast and stable driver circuit for 1394B PHY transmitter | AVIC XI'AN AERONAUTICS COMPUTING TECHNIQUE RES INST | 2016-05-04 | — | — | CN | claimed |
| CN-105552890-A | Security region volume based evaluation method for distribution system N-1 safe operation range | UNIV TIANJIN | 2016-05-04 | — | — | CN | claimed |
| CN-105515038-A | Method for tracking maximum power of wind energy based on improved fuzzy logic control algorithm | NAT UNIV DONG HWA | 2016-04-20 | — | — | CN | claimed |
| CN-105435486-A | Extraction solvent concentration stability control method for heat reflux extraction process | SUZHOU ZEDAXINGBANG MEDICAL TECH CO LTD | 2016-03-30 | — | — | CN | claimed |
| CN-105406472-A | Safety working range based (N-1) calibration method for main transformer of medium-voltage power distribution system | JIANGSU ELECTRIC POWER CO ECONOMIC RES INST | 2016-03-16 | — | — | CN | claimed |
| CN-105391068-A | Safe operation range based line N-1 verification method for medium-voltage power distribution system | JIANGSU ELECTRIC POWER CO ECONOMIC RES INST | 2016-03-09 | — | — | CN | claimed |
| CN-104392614-A | Jammed intersection signal timing method and traffic signal lamp control system | DENG RONGFENG | 2015-03-04 | — | — | CN | claimed |
| CN-104330272-A | Method, device and system for monitoring fatigue strength of boom structure and fire truck | CHANGSHA ZOOMLION FIRE FIGHTING VEHICLE CO | 2015-02-04 | — | — | CN | claimed |
| CN-104166374-A | Novel two-parameter tool location optimization algorithm for non-developable ruled surface five-axis side milling | UNIV XIANGTAN | 2014-11-26 | — | — | CN | claimed |
| CN-104053890-A | Method and control unit for determining a delay time of an exhaust gas sensor of an internal combustion engine | BOSCH GMBH ROBERT | 2014-09-17 | — | — | CN | claimed |
| CN-103913185-A | Brillouin optical fiber sensing system and method | UNIV GUANGXI NORMAL | 2014-07-09 | — | — | CN | claimed |
| CN-101918205-B | Method of manufacturing a tubular insulating device and corresponding device | CARBONE LORRAINE COMPOSANTS | 2014-06-25 | — | — | CN | claimed |
| CN-103760854-A | Fault-tolerable floor sweeping multi-robot method and system | SHENZHEN INST OF ADV TECH CAS | 2014-04-30 | — | — | CN | claimed |
| CN-102299676-B | Speed-regulation synchronous motor assembling unit | HAO YUSHAN | 2014-04-02 | — | — | CN | claimed |
| US-8263125-B2 | Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients | TORRENT PHARMACEUTICALS LIMITED (IN) | 2012-09-11 | — | — | US | claimed |
| EP-0514848-A2 | Process and apparatus for the generation of peroxyacids | Degussa Aktiengesellschaft (DE) | 1992-11-25 | — | — | EP | claimed |