Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methaqualone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methaqualone SCHEMBL43892 | 1.00 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29386732 | 1.00 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL20471677 | 1.00 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29849847 | 0.98 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL3500629 | 0.98 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29064194 | 0.97 | ALDH1A1 (0.94) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL16596956 | 0.86 | L3MBTL1 (0.77) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL1551501 | 0.85 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL19612477 | 0.85 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Etaqualone SCHEMBL466318 | 0.84 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1LMNANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 352 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260060949-A1 | METHOD FOR TREATING DAMAGE INDUCED BY SLEEP DEPRIVATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2026-03-05 | — | — | US | claimed |
| EP-4427297-B1 | SATELLITE PLATFORM AND METHOD FOR RECONFIGURING THE ELECTROMAGNETIC BEAM OF SUCH A SATELLITE PLATFORM | THALES SA (FR) | 2025-11-12 | — | — | EP | claimed |
| EP-3983127-B1 | PLASMA SEPARATION AND SAMPLE METERING DEVICE AND METHODS OF USE RELATED THERETO | SIEMENS HEALTHCARE DIAGNOSTICS INC (US) | 2025-04-23 | — | — | EP | claimed |
| CN-119728066-A | Frame structure definition and synchronous block mapping method for physical layer of power wireless private network | 重庆邮电大学 | 2025-03-28 | — | — | CN | claimed |
| CN-119624300-A | Complex network model construction system for unmanned aerial vehicle take-off and landing point site selection | 中国民用航空总局第二研究所 | 2025-03-14 | — | — | CN | claimed |
| CN-119541275-A | Unmanned aerial vehicle take-off and landing point candidate priority determining method, device, medium and equipment based on complex network model | 中国民用航空总局第二研究所 | 2025-02-28 | — | — | CN | claimed |
| CN-119516847-A | Unmanned aerial vehicle take-off and landing point site selection system based on take-off and landing point candidate priority | 中国民用航空总局第二研究所 | 2025-02-25 | — | — | CN | claimed |
| EP-3441087-B1 | METHODS OF TREATING CHRONIC PAIN | TEVA PHARMACEUTICALS INT GMBH (CH) | 2025-02-19 | — | — | EP | claimed |
| EP-4508434-A1 | PTX3 BIOMARKER FOR REDUCING ANTIBIOTIC TREATMENT IN NEWBORNS | bioMérieux (FR) | 2025-02-19 | — | — | EP | claimed |
| CN-119375377-A | Method for identifying kumquat variety and kumquat variety based on metabonomics and application | 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） | 2025-01-28 | — | — | CN | claimed |
| CN-115770105-A | Positioning device and positioning method for computer-assisted surgery | 澳特拉斯(北京)科技有限公司 | 2023-03-10 | — | — | CN | claimed |
| US-20220381696-A1 | METHOD AND DEVICE ASSEMBLY FOR PREDICTING A PARAMETER IN A BIOPROCESS BASED ON RAMAN SPECTROSCOPY AND METHOD AND DEVICE ASSEMBLY FOR CONTROLLING A BIOPROCESS | SARTORIUS STEDIM DATA ANALYTICS AB (SE) | 2022-12-01 | — | — | US | claimed |
| US-20220317110-A1 | DESIGN AND METHODS FOR MEASURING ANALYTES USING NANOFABRICATED DEVICE | Roche Sequencing Solutions, Inc. | 2022-10-06 | — | — | US | claimed |
| US-11439675-B2 | Method for treating damage induced by sleep deprivation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-09-13 | — | — | US | claimed |
| CN-114974594-A | System and method for training child emotion competence | 南京加信培优信息技术有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-114945945-A | Indicating camera parameters in point cloud decoding | 华为技术有限公司 | 2022-08-26 | — | — | CN | claimed |
| CN-216696542-U | Partial discharge monitoring circuit of transformer | 福建中电合创电力科技有限公司 | 2022-06-07 | — | — | CN | claimed |
| CN-114256983-A | Monitoring circuit is put in intelligence office | 福建中电合创电力科技有限公司 | 2022-03-29 | — | — | CN | claimed |
| CN-114195014-A | Automatic obstacle avoiding device and obstacle avoiding system for intelligent crane | 合肥市春华起重机械有限公司 | 2022-03-18 | — | — | CN | claimed |
| EP-3083657-B1 | PREPARATION OF MULTI-HAPTEN MUTANT G6PDH CONJUGATES AND THEIR USE FOR DETECTION OF MULTIPLE ANALYTES | SIEMENS HEALTHCARE DIAGNOSTICS INC (US) | 2022-01-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11439675-B2 | Method for treating damage induced by sleep deprivation | SI, CRY2, PER2 | ALDH1A1 388/4885L3MBTL1 2323/4885LMNA 1140/4885 |
| US-20260060949-A1 | METHOD FOR TREATING DAMAGE INDUCED BY SLEEP DEPRIVATION | ATP2A1, CHERP, ATP2A3 | ALDH1A1 3805/4885L3MBTL1 688/4885LMNA 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.