Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methaqualone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methaqualone SCHEMBL29386732 | 1.00 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29355239 | 1.00 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL20471677 | 1.00 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29849847 | 0.98 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL3500629 | 0.98 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL29064194 | 0.97 | ALDH1A1 (0.94) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL16596956 | 0.86 | L3MBTL1 (0.77) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| SCHEMBL1551501 | 0.85 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Methaqualone SCHEMBL19612477 | 0.85 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1LMNANPSR1TSHR | |
| Etaqualone SCHEMBL466318 | 0.84 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1LMNANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14942 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4690649-A1 | AN APPARATUS AND A METHOD FOR MANAGING DECENTRALIZED IDENTIFIERS, AN ENDPOINT STORING ENCRYPTED PERSONAL INFORMATION AND A DECENTRALIZED IDENTIFIER DOCUMENT | Sony Group Corporation (JP) | 2026-02-11 | — | — | EP | claimed |
| US-12525764-B2 | Devices for generation of electromagnetic radiation of predetermined profile | Terahertz Group Ltd. (IL) | 2026-01-13 | — | — | US | claimed |
| EP-4622640-A1 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF | Brightseed, Inc. (US) | 2025-10-01 | — | — | EP | claimed |
| US-12427532-B2 | Magnetic levitation system | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2025-09-30 | — | — | US | claimed |
| US-20250281451-A1 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF | BRIGHTSEED, INC. | 2025-09-11 | — | — | US | claimed |
| US-12383743-B2 | Treatment of addiction and dependency | TACA JR ARTURO C (US) | 2025-08-12 | — | — | US | claimed |
| US-12377065-B2 | Compositions for treatment of substance use disorder | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (US) | 2025-08-05 | — | — | US | claimed |
| WO-2025133616-A1 | CONJUGATED POLYMER NANOPARTICLE BIOSENSORS | STREAM BIO LTD (GB) | 2025-06-26 | — | — | WO | claimed |
| US-20250164495-A1 | METHODS FOR LABELING URINE IN A SUBJECT WITH FLUOROPHORES | UPTRU INC. (CA) | 2025-05-22 | — | — | US | claimed |
| EP-3983127-B1 | PLASMA SEPARATION AND SAMPLE METERING DEVICE AND METHODS OF USE RELATED THERETO | SIEMENS HEALTHCARE DIAGNOSTICS INC (US) | 2025-04-23 | — | — | EP | claimed |
| EP-0105361-A1 | ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1984-04-18 | — | — | EP | claimed |
| EP-0098426-A2 | Method of eliminating effects of spurious free induction decay NMR signal caused by imperfect 180 degrees RF pulses | GENERAL ELECTRIC COMPANY (US) | 1984-01-18 | — | — | EP | claimed |
| WO-1983003541-A1 | ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS | UNIV GEORGIA RES FOUND (US) | 1983-10-27 | — | — | WO | claimed |
| EP-0067998-A1 | METHOD FOR PROCESSING AN INFORMATION SIGNAL AND MEANS FOR CARRYING OUT THE METHOD. | LOEFBERG BO | 1983-01-05 | — | — | EP | claimed |
| WO-1982001273-A1 | METHOD FOR PROCESSING AN INFORMATION SIGNAL AND MEANS FOR CARRYING OUT THE METHOD | LOEFBERG B | 1982-04-15 | — | — | WO | claimed |
| US-4313736-A | USING SODIUM NITRITE | FISCHER JOHN F | 1982-02-02 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4107285-A | LABELLING, ANTIBODIES | HOFFMANN-LA ROCHE INC. (US) | 1978-08-15 | — | — | US | claimed |
| US-4054658-A | SEDATIVES, HYPNOSIS | WILLIAM H. RORER, INC. (US) | 1977-10-18 | — | — | US | claimed |
| US-4053459-A | ANTIBODY SPECIFIC TO METHAQUALONE AND ITS METABOLITES | HOFFMANN-LA ROCHE INC. (US) | 1977-10-11 | — | — | US | claimed |