Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11170910 | 0.82 | GAA (0.52) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL24769833 | 0.82 | POLB (0.55) | ALDH1A1KMT2ASMN1; SMN2MAPTRAB9A | |
| Iodide SCHEMBL11158727 | 0.79 | CYP19A1 (0.46) | ALDH1A1GAAMAPTLMNAPOLB | |
| Iodide SCHEMBL11167852 | 0.79 | GAA (0.46) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL11166212 | 0.78 | ALDH1A1 (0.51) | ALDH1A1GAAKMT2AMEN1MAPT | |
| Iodide SCHEMBL11445694 | 0.77 | LMNA (0.49) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11158117 | 0.77 | ALDH1A1 (0.51) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL11156405 | 0.77 | L3MBTL1 (0.49) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL11162951 | 0.77 | NPSR1 (0.51) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL11161499 | 0.75 | LMNA (0.46) | ALDH1A1GAAKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017484-A1 | 2-Imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-10-15 | — | — | EP | disclosed |