Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446519 | 0.88 | OPRM1 (0.44) | DRD3OPRM1OPRD1OPRK1KCNA3 | |
| SCHEMBL11446492 | 0.79 | DRD3 (0.56) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11446400 | 0.78 | OPRM1 (0.44) | DRD3OPRM1OPRD1OPRK1KCNA3 | |
| SCHEMBL19475378 | 0.74 | DRD3 (0.68) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11446518 | 0.74 | DRD3 (0.46) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL19717856 | 0.74 | DRD3 (0.64) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11456542 | 0.72 | SIGMAR1 (0.49) | OPRM1DRD2 | |
| Hydrochloric Acid SCHEMBL11454550 | 0.71 | SIGMAR1 (0.48) | OPRM1OPRD1OPRK1DRD2DRD4 | |
| SCHEMBL11458105 | 0.71 | DRD3 (0.67) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL614226 | 0.71 | OPRM1 (0.71) | DRD3OPRM1OPRD1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |