Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11455155 | 0.88 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11446940 | 0.88 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11446338 | 0.88 | ADRA1D (0.53) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL11446665 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11447378 | 0.83 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11454382 | 0.82 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11457094 | 0.82 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11447825 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11456755 | 0.79 | ADRA1D (0.56) | ALDH1A1LMNAMAPTMAPK1KMT2A | |
| SCHEMBL11456895 | 0.77 | LMNA (0.48) | ALDH1A1LMNAMAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |