Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11457094 | 0.92 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11465422 | 0.91 | GFER (0.50) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11454629 | 0.89 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11446875 | 0.88 | ADRA1D (0.52) | ALDH1A1KMT2AMEN1MAPTGAA | |
| SCHEMBL11446665 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11447284 | 0.84 | KMT2A (0.53) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11465438 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11447611 | 0.82 | ADRA1D (0.52) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL11446664 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1TSHRLMNA | |
| SCHEMBL11454733 | 0.82 | ADRA1D (0.53) | KMT2AMEN1LMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |