Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.49 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448078 | 0.89 | ADRB2 (0.48) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11446601 | 0.89 | HTR1A (0.46) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11447082 | 0.89 | IGF1R (0.46) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11446224 | 0.86 | HTR1A (0.63) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11446599 | 0.85 | ADRA1D (0.51) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11446219 | 0.84 | ADRA1D (0.45) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11457400 | 0.84 | ADRA1D (0.53) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11454600 | 0.83 | USP2 (0.47) | HTR1AHTR7KDM4EALDH1A1 | |
| SCHEMBL11456957 | 0.82 | ALDH1A1 (0.47) | ADRB2ADRB1ADRB3ADRA1DADRA1A | |
| SCHEMBL11446384 | 0.82 | ADRA1D (0.43) | ADRB2ADRB1ADRB3ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |