Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465422 | 0.92 | GFER (0.50) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11446709 | 0.91 | GFER (0.54) | KMT2AMEN1GFERMAPTMAPK1 | |
| SCHEMBL11457094 | 0.89 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11465438 | 0.88 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11446665 | 0.87 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11454733 | 0.85 | ADRA1D (0.53) | KMT2AMEN1GFERMAPTMAPK1 | |
| SCHEMBL11454382 | 0.84 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11447731 | 0.82 | GFER (0.60) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11454629 | 0.82 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1TSHRGFER | |
| SCHEMBL11446383 | 0.79 | HTR1A (0.59) | KMT2AMEN1GFERMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |