Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209224 | 0.77 | TSHR (0.55) | RIPK1TSHRRECQLSLC2A1PYCR1 | |
| SCHEMBL9214534 | 0.77 | TSHR (0.55) | RIPK1TSHRRECQLSLC2A1PYCR1 | |
| SCHEMBL9824208 | 0.75 | RIPK1 (0.64) | RIPK1TSHRRECQLSLC2A1PYCR1 | |
| SCHEMBL1041082 | 0.69 | PNMT (0.56) | RIPK1TSHRRECQLSLC2A1MAOB | |
| SCHEMBL14540715 | 0.69 | RIPK1 (0.59) | RIPK1TSHRRECQLSLC2A1PYCR1 | |
| SCHEMBL25711795 | 0.69 | RIPK1 (0.59) | RIPK1TSHRRECQLPYCR1ALOX5 | |
| SCHEMBL30798978 | 0.68 | TAAR1 (0.66) | RIPK1TSHRRECQLPYCR1ALDH1A1 | |
| SCHEMBL8290710 | 0.68 | TAAR1 (0.66) | RIPK1TSHRRECQLPYCR1ALDH1A1 | |
| SCHEMBL29565507 | 0.67 | RIPK1 (0.65) | RIPK1TSHRRECQLPYCR1ALOX5 | |
| SCHEMBL17278345 | 0.67 | RIPK1 (0.61) | RIPK1TSHRRECQLPYCR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4200754-A | Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | SMITHKLINE CORPORATION (US) | 1980-04-29 | — | — | US | claimed |
| US-4200754-A | Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | SMITHKLINE CORPORATION (US) | 1980-04-29 | — | — | US | disclosed |
| US-4200754-A | Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | SMITHKLINE CORPORATION (US) | 1980-04-29 | — | — | US | disclosed |