Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540715 | 0.88 | RIPK1 (0.59) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL9824208 | 0.82 | RIPK1 (0.64) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL17278345 | 0.79 | RIPK1 (0.61) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL29565507 | 0.79 | RIPK1 (0.65) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL17887629 | 0.78 | RIPK1 (0.58) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL14946472 | 0.76 | RIPK1 (0.60) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL14344795 | 0.76 | RIPK1 (0.56) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL9209224 | 0.75 | TSHR (0.55) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL9214534 | 0.75 | TSHR (0.55) | RIPK1TSHRRECQLAOC3GAA | |
| SCHEMBL17882179 | 0.75 | RIPK1 (1.00) | RIPK1AOC3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023092094-A2 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2023-05-25 | — | — | WO | disclosed |