Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 5/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450310 | 0.99 | POLB (0.48) | POLBLTA4HCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11448946 | 0.83 | LTA4H (0.51) | POLBLTA4HCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL6535642 | 0.81 | CHRNB4 (0.49) | POLBLTA4HSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL28209549 | 0.81 | POLB (0.47) | POLBLTA4HCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11466657 | 0.80 | POLB (0.43) | POLBLTA4HCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL8493732 | 0.80 | POLB (0.59) | POLBLTA4HCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11455640 | 0.78 | GHSR (0.50) | LTA4H | |
| SCHEMBL11455779 | 0.78 | GHSR (0.49) | POLBLTA4HCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11449265 | 0.78 | SLC6A3 (0.48) | POLBLTA4HSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL11456857 | 0.78 | LTA4H (0.46) | POLBLTA4HCACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |
| EP-0004288-A2 | Phenoxyalkyl amines, pharmaceutical compositions containing them, and process for their preparation | MERCK PATENT GmbH (DE) | 1979-10-03 | — | — | EP | disclosed |