Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11449386 | 0.97 | GHSR (0.39) | LTA4HGHSRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11449145 | 0.89 | LTA4H (0.40) | LTA4HPOLBGHSRSLC6A2SLC6A4 | |
| SCHEMBL11448396 | 0.85 | GHSR (0.45) | LTA4HPOLBGHSRSLC6A2SLC6A4 | |
| SCHEMBL11456914 | 0.85 | LTA4H (0.54) | LTA4HSLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL11448946 | 0.85 | LTA4H (0.51) | LTA4HPOLBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11455787 | 0.84 | LTA4H (0.51) | LTA4HPOLBSLC6A4 | |
| SCHEMBL11455711 | 0.83 | POLB (0.39) | LTA4HPOLBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11466693 | 0.82 | GHSR (0.48) | LTA4HGHSRSLC6A2SLC6A4 | |
| SCHEMBL11458069 | 0.82 | SLC6A4 (0.53) | LTA4HSLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL11448239 | 0.82 | LTA4H (0.46) | LTA4HPOLBGHSRSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225608-A | ANTIDEPRESSANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1980-09-30 | — | — | US | disclosed |