Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11341305 | 0.96 | SIGMAR1 (0.45) | SIGMAR1POLBTRPM8ALOX5MAPT | |
| SCHEMBL11465401 | 0.88 | ALDH1A1 (0.43) | SIGMAR1TRPM8CHRM3CHRM2OPRM1 | |
| SCHEMBL11572457 | 0.87 | TSHR (0.41) | SIGMAR1POLBTRPM8ALOX5MAPT | |
| SCHEMBL11337743 | 0.85 | SIGMAR1 (0.42) | SIGMAR1POLBOPRM1OPRK1 | |
| SCHEMBL11571013 | 0.85 | SLC18A3 (0.44) | SIGMAR1TRPM8CHRM3CHRM2OPRM1 | |
| SCHEMBL11350705 | 0.84 | ALDH1A1 (0.45) | SIGMAR1POLBTRPM8CHRM3CHRM2 | |
| SCHEMBL11347000 | 0.83 | SIGMAR1 (0.41) | SIGMAR1POLBTRPM8MAPT | |
| SCHEMBL11450446 | 0.83 | POLB (0.45) | SIGMAR1POLBTRPM8MAPTCHRM3 | |
| SCHEMBL11330427 | 0.82 | SLC18A3 (0.46) | SIGMAR1TRPM8MAPTCHRM3CHRM2 | |
| SCHEMBL11337740 | 0.79 | ALDH1A1 (0.41) | SIGMAR1POLBTRPM8CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4204003-A | N-(2-Aminocyclopentyl)-N-alkanoylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4159340-A | N-(2-Aminocyclopentyl)-N-acylanilides as CNS anti-depressants | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4157398-A | N-(2-Aminocyclopentyl)acylanilides and treating depression | THE UPJOHN COMPANY (US) | 1979-06-05 | — | — | US | disclosed |
| US-4156733-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-05-29 | — | — | US | disclosed |
| US-4156015-A | N-(2-Aminocyclopentyl)acylanilides and treating depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |
| US-4148913-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-04-10 | — | — | US | disclosed |