Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446372 | 0.83 | OPRK1 (0.44) | HTR7OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL11447147 | 0.82 | OPRM1 (0.46) | HTR7OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL11446845 | 0.80 | OPRM1 (0.42) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11455002 | 0.80 | OPRM1 (0.42) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11466052 | 0.78 | OPRM1 (0.43) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11446213 | 0.76 | DRD3 (0.41) | HTR7OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL11446493 | 0.75 | OPRM1 (0.45) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11446888 | 0.75 | DRD3 (0.38) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL9053106 | 0.74 | DRD3 (0.72) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| Diamocaine SCHEMBL29358950 | 0.74 | DRD3 (0.53) | OPRM1OPRK1OPRD1OPRL1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |