Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11662561 | 0.90 | DRD3 (0.48) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11446399 | 0.90 | DRD3 (0.51) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11465399 | 0.90 | DRD3 (0.44) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11446492 | 0.89 | DRD3 (0.56) | DRD3OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL11447147 | 0.86 | OPRM1 (0.46) | DRD3OPRM1OPRD1OPRK1ADRA1A | |
| SCHEMBL11446213 | 0.84 | DRD3 (0.41) | DRD3OPRM1OPRD1OPRK1ADRA1A | |
| SCHEMBL11662564 | 0.84 | DRD3 (0.39) | DRD3OPRM1OPRD1OPRK1ADRA1A | |
| SCHEMBL11605365 | 0.83 | SIRT2 (0.39) | DRD3ADRA1AHTR1AHTR7 | |
| SCHEMBL11446528 | 0.81 | DRD2 (0.50) | OPRM1DRD2 | |
| SCHEMBL11465441 | 0.80 | ADRA1A (0.42) | DRD3OPRM1OPRD1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |