Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465399 | 0.89 | DRD3 (0.44) | ADRA1AADRA1DADRA1BDRD3DRD2 | |
| SCHEMBL11446845 | 0.87 | OPRM1 (0.42) | ADRA1ADRD3ALDH1A1OPRM1OPRD1 | |
| SCHEMBL11446888 | 0.85 | DRD3 (0.38) | ADRA1ADRD3OPRM1OPRD1OPRK1 | |
| SCHEMBL11456856 | 0.84 | DRD2 (0.46) | DRD3DRD2DRD4ALDH1A1OPRM1 | |
| SCHEMBL11454803 | 0.80 | DRD3 (0.57) | ADRA1ADRD3DRD2DRD4OPRM1 | |
| SCHEMBL11455002 | 0.78 | OPRM1 (0.42) | ADRA1ADRD3OPRM1OPRD1OPRK1 | |
| SCHEMBL11447099 | 0.77 | HTR7 (0.52) | DRD3DRD2 | |
| SCHEMBL11466052 | 0.76 | OPRM1 (0.43) | ADRA1AADRA1DADRA1BDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL11447560 | 0.76 | HTR7 (0.51) | ADRA1AADRA1DADRA1BDRD3DRD2 | |
| SCHEMBL11447147 | 0.76 | OPRM1 (0.46) | ADRA1ADRD3OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |