Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CDC42 | P60953 | 1/20 | 0.47 |
| ▸ | RAC1 | P63000 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18770095 | 1.00 | TDP1 (0.50) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL28351309 | 0.84 | TAS1R3 (0.51) | PTGS2PTGS1MT-CO2TAS1R3TAS1R1 | |
| SCHEMBL11476903 | 0.83 | PTGS2 (0.58) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL30882142 | 0.82 | PTGS2 (0.43) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL29226110 | 0.82 | PTGS2 (0.43) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL11764188 | 0.79 | PTGS2 (0.55) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL11719691 | 0.79 | PTGS2 (0.42) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL11742200 | 0.79 | PTGS2 (0.57) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL505819 | 0.78 | TDP1 (0.77) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 | |
| SCHEMBL505811 | 0.78 | TDP1 (0.77) | TDP1L3MBTL1PTGS2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039244-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | UNIV PENNSYLVANIA (US) | 2023-02-09 | — | — | US | disclosed |
| US-11459295-B2 | 2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-10-04 | — | — | US | disclosed |
| US-20180305305-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2018-10-25 | — | — | US | disclosed |
| WO-2017070448-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-04-27 | — | — | WO | disclosed |
| US-4207241-A | ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS AND ANTIPRURITIC AGENTS | SYNTEX CORPORATION (US) | 1980-06-10 | — | — | US | disclosed |
| US-4097674-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANTIPRURITIC AGENTS, ANALGESICS | SYNTEX CORPORATION (US) | 1978-06-27 | — | — | US | disclosed |
| US-4051233-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1977-09-27 | — | — | US | disclosed |
| US-4001301-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, ANTI-PRURITIC | SYNTEX CORPORATION (PM) | 1977-01-04 | — | — | US | disclosed |
| US-3998966-A | Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof | SYNTEX CORPORATION (PM) | 1976-12-21 | — | — | US | disclosed |
| US-3980699-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-09-14 | — | — | US | disclosed |
| US-3978116-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |
| US-3978124-A | ANALGESIC, ANTIPYRETIC | SYNTEX CORPORATION (PM) | 1976-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11459295-B2 | 2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same | AKR1C3, AKR1C2, AKR1A1 | TDP1 2069/4885L3MBTL1 4757/4885PTGS2 294/4885 |
| US-20180305305-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | AKR1C3, AKR1C2, AKR1A1 | TDP1 2069/4885L3MBTL1 4757/4885PTGS2 294/4885 |
| US-20230039244-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | AKR1C3, AKR1C2, AKR1A1 | TDP1 2106/4885L3MBTL1 4746/4885PTGS2 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.